| Gene Name |
ZBTB48 |
| Synonyms |
0610011D15Rik;AI327031;GLI Kruppel family member HKR3;HKR3;Krueppel related zinc finger protein 3;Krueppel-related zinc finger protein 3;OTTMUSP00000031803;pp9964;Protein HKR3;RP23-445E20.3;ZBT48_HUMAN;ZBTB 48;Zbtb48;Zinc finger and BTB domain containing 48;Zinc finger and BTB domain containing protein 48;Zinc finger and BTB domain-containing protein 48;Zinc finger protein 855;ZNF855 |
| English Name |
Recombinant human ZBTB48 protein |
| Full Name |
zinc finger and BTB domain containing 48 |
| Chinese Name |
含BTB结构域锌指蛋白48 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
P10074 |
| Gene ID |
3104 |
| Reactivity |
Human Mouse (Orangutan) |
| Molecular Weight |
39kDa |
| Interval Range |
1-350aa |
| Background |
Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411).Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411).Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411).Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257).Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257).Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177).Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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