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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > ApitolisibCAS：1032754-93-0
Molecular Formula：C23H30N8O3S
Molecular Weight：498.6
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1032754-93-0 |
| Name | Apitolisib |
| Molecular Formula | C23H30N8O3S |
| Molecular Weight | 498.6 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD20274520 |
| SMILES | CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[C@H](C)O |
| Target Point | PI3K，mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | Apitolisib is a potent PI3K and mTOR (TORC1/2) kinase inhibitor, inhibits the activity of PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ. |
| Biological Activity | Apitolisib (GDC-0980) 是一种口服有效的 PI3K 和 mTOR (TORC1/2) 激酶抑制剂，抑制 PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ 的活性，IC50 值为 5 nM/27 nM/7 nM/14 nM。 抑制mTOR，Ki 为 17 nM。[1-2] |
| Data Literature Source | [1]. Sutherlin DP，et al. Discovery of a potent，selective，and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. J Med Chem，2011，54(21)，7579-7587. [2]. Wallin JJ，et al. GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Mol Cancer Ther，2011，10(12)，2426-2436 |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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