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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > BX-517CAS：850717-64-5
Molecular Formula：C15H14N4O2
Molecular Weight：282.3
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 850717-64-5 |
| Name | BX-517 |
| Molecular Formula | C15H14N4O2 |
| Molecular Weight | 282.3 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | NC(NC1=CC=C(NC(/C2=C(C)\C3=CC=CN3)=O)C2=C1)=O |
| Target Point | PDK-1 |
| Passage | PI3K/Akt/mTOR |
| Background | BX-517 is a potent and selective PDK1 inhibitor. |
| Biological Activity | BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.[1] |
| IC50 | 6nM(PDK1)[1] |
| Data Literature Source | [1]. Islam I，et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3819-25. [2]. Islam I，et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design，synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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