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Cabozantinib Malate

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Cat.No：IC2250 Solarbio

CAS：1140909-48-3

Molecular Formula：C₂₈H₂₄FN₃O₅·C₄H₆O₅

Molecular Weight：635.59

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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CAS	1140909-48-3
Name	Cabozantinib Malate
Molecular Formula	C₂₈H₂₄FN₃O₅·C₄H₆O₅
Molecular Weight	635.59
Solubility	Soluble in DMSO ≥2mg/mL;Soluble in Water ＜ 1mg/mL
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 691-711-0
MDL	MFCD20923480
SMILES	O=C([C@H](CC(O)=O)O)O.O=C(NC1=CC=C(C=C1)OC2=CC=NC3=CC(OC)=C(C=C23)OC)C4(CC4)C(NC5=CC=C(C=C5)F)=O
Target Point	VEGFR
Passage	Angiogenesis;Protein Tyrosine Kinase/RTK
Background	Cabozantinib Malate is a potent multi-receptor tyrosine kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3.
Biological Activity	Cabozantinib (S-malate)是一种有效的多受体酪氨酸激酶抑制剂，抑制VEGFR2，c-Met，Kit，Axl 和 Flt3 的 IC50 分别为0.035，1.3，4.6，7 和 11.3 nM。[1-3]
Data Literature Source	[1]. You WK，et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res，2011，71(14)，4758-4768. [2]. Torres KE，et al. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clin Cancer Res，2011，17(12)，3943-3955. [3]. Yakes FM，et al. Cabozantinib (XL184)，a novel MET and VEGFR2 inhibitor，simultaneously suppresses metastasis，angiogenesis，and tumor growth. Mol Cancer Ther，2011，10(12)，2298-2308
Unit	Bottle
Specification	5mg 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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