| English Name |
Anti-KAT2A Polyclonal Antibody |
| Chinese Name |
组蛋白乙酰基转移酶GCN5抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Predicted Reactivity |
Zebrafish |
| Dilution Ratio |
IHC 1:50-200. |
| Target |
KAT2A |
| Synonyms |
1110051E14Rik, AW212720, EC 2.3.1.48, GCN 5, Gcn5, GCN5 general control of amino acid synthesis 5 like 2, GCN5 general control of amino-acid synthesis 5-like 2 (yeast), GCN5 like 2, GCN5L2, general control of amino acid synthesis 5-like 2, General control of amino acid synthesis protein 5 like 2, General control of amino acid synthesis protein 5-like 2, General control of amino acid synthesis yeast homolog like 2, General control of amino acid synthesis, yeast, homolog-like 2, HGCN 5, HGCN5, Histone acetyltransferase GCN5, Histone acetyltransferase KAT2A, hsGCN5, K(lysine) acetyltransferase 2A, KAT2 A, KAT2A, KAT2A_HUMAN, Lysine acetyltransferase 2A, MGC102791, PCAF-b, STAF97 |
| Background |
Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:27796307, PubMed:29174768). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). |
| Swiss Prot |
Q92830 |
| Gene ID |
2648 |
| Subcellular Location |
Cytoplasm Nucleus |
| Immunogen |
A synthetic peptide of human KAT2A |
| Public Immunogen Range |
750-800/837aa |
| Calculated MW |
49/94kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
| Piece |
Piece |
| Specification |
50ul 100ul |
| Reactivity |
Human Mouse |
| Application |
IHC |
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