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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > CH-5132799CAS：1007207-67-1
Molecular Formula：C15H19N7O3S
Molecular Weight：377.42
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1007207-67-1 |
| Name | CH-5132799 |
| Molecular Formula | C15H19N7O3S |
| Molecular Weight | 377.42 |
| Solubility | Soluble in DMSO ≥0.5mg/mL;Soluble in Water ＜ 1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years |
| MDL | MFCD22419020 |
| SMILES | NC1=NC=C(C2=C3C(N(S(=O)(C)=O)CC3)=NC(N4CCOCC4)=N2)C=N1 |
| Target Point | PI3K |
| Passage | PI3K/Akt/mTOR |
| Background | CH5132799 is a selective class I PI3K inhibitor. . |
| Biological Activity | Izorlisib (CH5132799) is a selective class I PI3K inhibitor. Izorlisib inhibits class I PI3Ks， particularly PI3Kα， with an IC50 of 14 nM.[1-2] |
| Data Literature Source | [1]. Tanaka H，et al. The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. Clin Cancer Res，2011，17(10)，3272-3281. [2]. Ohwada J，et al. Discovery and biological activity of a novel class I PI3K inhibitor，CH5132799. Bioorg Med Chem Leff，2011，21(6)，1767-1772. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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