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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > WortmanninCAS：19545-26-7
Molecular Formula：C23H24O8
Molecular Weight：428.43
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 19545-26-7 |
| Name | Wortmannin |
| Molecular Formula | C23H24O8 |
| Molecular Weight | 428.43 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 214-538-0 |
| MDL | MFCD00133927 |
| SMILES | O=C1C([C@@](CC2)([H])[C@@]3(C)C2=O)=C([C@H](OC(C)=O)C3)[C@]4(C)C5=C1OC=C5C(O[C@@H]4COC)=O |
| Target Point | PI3K；Polo-like Kinase (PLK)； DNA-PK；Autophagy |
| Passage | Autophagy |
| Background | It is an effective, irreversible, and selective PI3K inhibitor. It can also inhibit the formation of autophagosomes, and effectively inhibit DNA-PK/ATM and Polo-like kinase 1 (PlK1). |
| Data Literature Source | [1]. Yano H，et al. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem，1993，268(34)，25846-25856. [2]. Sarkaria JN，et al. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res，1998，58(19)，4375-4382. [3]. Nakanishi S，et al. Wortmannin，a microbial product inhibitor of myosin light chain kinase. J Biol Chem，1992，267(4)，2157-2163. [4]. Ng SS，et al. Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin Cancer Res，2001，7(10)，3269-3275. [5]. Teranishi F，et al. Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastasis in vivo. Cancer Sci. 2009 Apr;100(4):770-7. [6]. Liu Y，et al. Polo-like kinases inhibited by Wortmannin. Labeling site and downstream effects. J Biol Chem. 2007 Jan 26;282(4):2505-11 |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Luo C, et al. APOPTOSIS, 2020(20).
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