{{cart_num}}
My Cart
CAS：143664-11-3
Molecular Formula：C34H33N3O5
Molecular Weight：563.64292
Storage：Store at 2-8℃，3 years
Purity：≥98%
Qty：
Size：
| Name | Elacridar |
| CAS | 143664-11-3 |
| Molecular Formula | C34H33N3O5 |
| Molecular Weight | 563.64292 |
| Storage | Store at 2-8℃，3 years |
| Purity | ≥98% |
| Unit | Piece |
| Specification | 10mg |
Biological Activity:
Elacridar (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.
Target: P-glycoprotein
In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects.
Solvent & Solubility: 10 mM in DMSO
备注：产品信息可能会有优化升级。请以实际标签信息为准。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
