English Name |
Anti-IL4R Polyclonal Antibody |
Chinese Name |
白细胞介素4受体抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
IHC 1:100-300. |
Target |
IL4R |
Synonyms |
CD124, IL 4R alpha, IL-4 receptor subunit alpha, IL-4-binding protein, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, IL4-BP, Il4r, IL4R nirs variant 1, IL4RA, IL4RA_HUMAN, Interleukin 4 receptor alpha chain, Interleukin 4 receptor, sIL4Ralpha/prot, Soluble IL-4 receptor subunit alpha, Soluble IL-4R-alpha, Soluble interleukin-4 receptor subunit alpha |
Background |
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. |
Swiss Prot |
P24394 |
Gene ID |
3566 |
Subcellular Location |
Cell membrane Secreted |
Immunogen |
A synthetic peptide of human IL4R |
Public Immunogen Range |
410-460/825aa |
Calculated MW |
26/88/90kDa |
Purification Method |
Octanoic acid-ammonium sulfate precipitation |
Storage Buffer |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Human |
Application |
IHC |