| English Name |
Anti-BCAR3 Polyclonal Antibody |
| Chinese Name |
乳腺癌抗雌激素抗性蛋白3抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Dilution Ratio |
WB 1:1000-3000.;IHC 1:50-200. |
| Target |
BCAR3 |
| Synonyms |
BCAR 3,BCAR3,BCAR3_HUMAN,Breast cancer anti estrogen resistance 3,Breast cancer anti estrogen resistance protein 3,Breast cancer anti-estrogen resistance protein 3,Breast cancer antiestrogen resistance 3,dJ1033H22.2,dJ1033H22.2 breast cancer anti estrogen resistance 3,dJ1033H22.2 breast cancer antiestrogen resistance 3,KIAA0554,Novel SH2 containing protein 2,Novel SH2-containing protein 2,NSP 2,NSP2,SH2 containing protein Nsp2,SH2 domain containing protein 3B,SH2 domain-containing protein 3B,SH2D3B |
| Background |
Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). |
| Swiss Prot |
O75815 |
| Gene ID |
8412 |
| Subcellular Location |
Cytoplasm |
| Immunogen |
A synthetic peptide of human BCAR3 |
| Public Immunogen Range |
430-480/825aa |
| Calculated MW |
56/82/93kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
| Piece |
Piece |
| Y-Dilution Ratio |
WB 1:1000-3000. IHC 1:50-200. |
| Specification |
50ul 100ul |
| Reactivity |
Human |
| Application |
IHC WB |
English
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