| English Name |
Anti-ITGAV Polyclonal Antibody |
| Chinese Name |
整合素αV抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Predicted Reactivity |
Cow;Chicken |
| Dilution Ratio |
IHC 1:100-300. |
| Target |
ITGAV |
| Synonyms |
Integrin alpha V, CD 51, CD51, CD51 antigen, HGNC, ITGAV, Msk 8, Msk8, Vitronectin receptor alpha polypeptide, Vitronectin receptor alpha polypeptide antigen CD51, Vitronectin receptor subunit alpha, VNRA, ITAV_HUMAN, Integrin alpha-V heavy chain, Integrin alpha-V light chain, Integrin alpha-V Precursor |
| Background |
The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. ITGAV:ITGB3 act as a receptor for CD40LG. |
| Swiss Prot |
P06756 |
| Gene ID |
3685 |
| Subcellular Location |
Cell membrane Cytoplasm |
| Immunogen |
A synthetic peptide of human ITGAV |
| Public Immunogen Range |
125-175/1048aa |
| Calculated MW |
112/116kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
| Piece |
Piece |
| Specification |
50ul 100ul |
| Reactivity |
Human Mouse |
| Application |
IHC |
English
中文
Manual Download
