| English Name |
Anti-UGT1A9 Polyclonal Antibody |
| Chinese Name |
UDP葡萄糖醛酸转移酶1A9抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Dilution Ratio |
WB 1:1000-3000;IHC 1:100-300. |
| Target |
UGT1A9 |
| Synonyms |
HLUGP4,LUGP4,UDPGT,UDPGT 1-9,UGT-1I,UGT1-09,UGT1-9,UGT1.9,UGT1A9S,UGT1AI,UGT1I |
| Background |
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:15470161, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:19545173). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:20610558). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212).Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. |
| Swiss Prot |
O60656 |
| Gene ID |
54600 |
| Subcellular Location |
Cytoplasm |
| Immunogen |
Recombinant protein of human UGT1A9 |
| Public Immunogen Range |
180-480aa |
| Calculated MW |
50/60kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
| Piece |
Piece |
| Y-Dilution Ratio |
WB 1:1000-3000. IHC 1:100-300. |
| Specification |
50ul 100ul |
| Reactivity |
Mouse Human |
| Application |
IHC WB |
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