English Name |
Anti-IPO5 Polyclonal Antibody |
Chinese Name |
输入蛋白5抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:1000-3000. ;IHC 1:50-200. |
Target |
IPO5 |
Synonyms |
IPO 5, IPO5, IPO5_HUMAN, Karyopherin beta 3, Karyopherin beta-3, KPNB3, MGC2068, Pse1, Ran binding protein 5, Ran GTP binding protein 5, Ran-binding protein 5, RanBP 5, RanBP5, IMB3,KPNB3,Pse1,RANBP5,imp5 |
Background |
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. |
Swiss Prot |
O00410 |
Gene ID |
3843 |
Subcellular Location |
Cytoplasm Nucleus |
Immunogen |
Recombinant protein of human IPO5 |
Public Immunogen Range |
1-350aa |
Calculated MW |
117/124/126kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Y-Dilution Ratio |
WB 1:1000-3000. IHC 1:50-200. |
Specification |
50ul 100ul |
Reactivity |
Human Monkey Mouse |
Application |
WB IHC |