{{cart_num}}
My CartMolecular Formula：C64H92N17O26P1
Molecular Weight：1546.51
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
Qty：
Size：
| Product Type | Peptides |
| Sequence(1LC) | DSPPQ-pS-PTFPEAGH |
| Sequence(3LC) | Asp-Ser-Pro-Pro-Gln-pSer-Pro-Thr-Phe-Pro-Glu-Ala-Gly-His |
| Molecular Formula | C64H92N17O26P1 |
| Molecular Weight | 1546.51 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Other Peptides |
| Background | This phospho-peptide is derived from human acetyl-CoA carboxylase 1 (ACC1) residue 1258-1271. ACC1 is an enzyme with crucial roles in de novo fatty acid biosynthesis and cancer cell survival. This enzyme catalyzes the first and rate-limiting step of de novo fatty acid biosynthesis. Many lines of evidence suggest that up-regulation of fatty acid biosynthesis is required for carcinogenesis, as more than 90% of the lipids are synthesized through de novo lipogenesis in cancer cells. BRCA1 significantly reduces the rate of fatty acid biosynthesis when complexed with ACC1. The crystal structure of human BRCA1 and this phospho-peptide provides structural evidence for direct interactions between BRCA1 and ACC1, which may be the molecular basis for the regulation of lipid biosynthesis by BRCA1. |
| Reference | [1] Shen, Y. et al. Biochemistry 47, 5767 (2008). |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no experimental images.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
