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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > CrenolanibCAS：670220-88-9
Molecular Formula：C26H29N5O2
Molecular Weight：443.54
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
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| CAS | 670220-88-9 |
| Name | Crenolanib |
| Molecular Formula | C26H29N5O2 |
| Molecular Weight | 443.54 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD21609260 |
| SMILES | NC1CCN(C2=CC=CC3=C2N=C(N4C5=CC=C(C=C5N=C4)OCC6(COC6)C)C=C3)CC1 |
| InChIKey | DYNHJHQFHQTFTP-UHFFFAOYSA-N |
| InChI | InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3 |
| PubChem CID | 10366136 |
| Target Point | PDGFR;FLT3 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Crenolanib is a potent and selective PDGFRα/β inhibitor that also potently inhibits FLT3. |
| Biological Activity | Crenolanib is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with Kds of 0.74 nM and 2.1 nM/3.2 nM， respectively.[1-3] |
| Data Literature Source | [1]. Heinrich MC， et al.Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with STI571-resistant gastrointestinal stromal tumors. Clin Cancer Res， 2012， Jun 27. [2]. Mathias TJ， et al. The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations. Invest New Drugs. 2015 Apr;33(2):300-9. [3]. Wang P， et al. Crenolanib， a PDGFR inhibitor， suppresses lung cancer cell proliferation and inhibits tumor growth in vivo. Onco Targets Ther. 2014 Sep 26;7:1761-8. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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