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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > PF-AKT400CAS：1004990-28-6
Molecular Formula：C20H22F2N6O
Molecular Weight：400.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1004990-28-6 |
| Name | PF-AKT400 |
| Molecular Formula | C20H22F2N6O |
| Molecular Weight | 400.43 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CCC1=CNC2=C1C(=NC=N2)N3CC[C@@](C3)(CNC(=O)C4=C(C=C(C=C4)F)F)N |
| InChIKey | MOZRQQTUYAYCQT-FQEVSTJZSA-N |
| InChI | InChI=1S/C20H22F2N6O/c1-2-12-8-24-17-16(12)18(27-11-26-17)28-6-5-20(23，10-28)9-25-19(29)14-4-3-13(21)7-15(14)22/h3-4，7-8，11H，2，5-6，9-10，23H2，1H3，(H，25，29)(H，24，26，27)/t20-/m0/s1 |
| PubChem CID | 25061501 |
| Target Point | Akt |
| Passage | PI3K/Akt/mTOR |
| Background | PF-AKT400 is a potent, ATP-competitive and selective Akt inhibitor. |
| Biological Activity | PF-AKT400 is a broadly selective， potent， ATP-competitive Akt inhibitor， displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM).[1-2] |
| IC50 | PKBα:0.5nM;PKA:450nM[1] |
| Data Literature Source | [1]. Chen SF，et al. Binding selectivity studies of PKBα using molecular dynamics simulation and free energy calculations. J Mol Model. 2013 Nov;19(11):5097-5112. [2]. Freeman-Cook KD，et al. Design of selective，ATP-competitive inhibitors of Akt. J Med Chem. 2010 Jun 24;53(12):4615-4622. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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