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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > SEA0400CAS：223104-29-8
Molecular Formula：C21H19F2NO3
Molecular Weight：371.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to brown Solid
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| CAS | 223104-29-8 |
| Name | SEA0400 |
| Molecular Formula | C21H19F2NO3 |
| Molecular Weight | 371.38 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD07772188 |
| SMILES | NC1=CC(OCC)=CC=C1OC2=CC=C(OCC3=CC(F)=CC=C3F)C=C2 |
| InChIKey | YSUBLPUJDOWYDP-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3 |
| PubChem CID | 644100 |
| Target Point | NCX |
| Passage | Membrane Transporter&Ion Channel |
| Background | SEA0400 is a selective inhibitor of Na+-Ca2+ exchanger. |
| Biological Activity | SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX)， inhibiting Na+-dependent Ca2+ uptake in cultured neurons， astrocytes， and microglia with IC50s of from 5 to 33 nM.[1-3] |
| IC50 | IC50: 5-33 nM (NCX)[1-3] |
| Data Literature Source | [1]. Matsuda T， et al. SEA0400， a novel and selective inhibitor of the Na+-Ca2+ exchanger， attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther. 2001 Jul;298(1):249-56. [2]. Nashida T， et al. The specific Na(+)/Ca(2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells. Neurochem Int. 2011 Aug;59(1):51-8. [3]. Ago Y， et al. SEA0400， a specific Na+/Ca2+ exchange inhibitor， prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinsons disease. Neuropharmacology. 2011 Dec;61(8):1441-51. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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