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SL 0101-1

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Cat.No：IS3250 Solarbio

CAS：77307-50-7

Molecular Formula：C₂₅H₂₄O₁₂

Molecular Weight：516.45

Storage：Powder:2-8℃，2 years

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	77307-50-7
Name	SL 0101-1
Molecular Formula	C₂₅H₂₄O₁₂
Molecular Weight	516.45
Solubility	Soluble in ---
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years
MDL	MFCD09842349
SMILES	OC1=CC(O)=C(C(C(O[C@@H]2O[C@@H](C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]2O)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1
InChIKey	SXOZSDJHGMAEGZ-IGKKHSBFSA-N
InChI	InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-30,32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1
PubChem CID	10459196
Target Point	Ribosomal S6 Kinase (RSK)
Passage	MAPK
Background	SL 0101-1 is a selective, reversible, ATP-competitive inhibitor of p90 ribosomal S6 kinase (RSK).
Biological Activity	SL 0101-1 (SL0101)， a kaempferol glycoside， isolated from the tropical plant F. refracta， is a cell-permeable， selective， reversible， ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor， with an IC50 of 89 nM[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor， with a Ki of 1 μM[2].
IC50	RSK1
Data Literature Source	[1]. Smith JA，et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34. [2]. Yu Li，et al. The Affinity of RSK for Cylitol Analogues of SL0101 Is Critically Dependent on the B-ring C-4'-hydroxy. Chem Commun (Camb). 2020 Mar 10;56(20):3058-3060.
Unit	Bottle
Specification	1mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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