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My CartReactivity：Human,Mouse,Rat
Application：WB,IHC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：10296
Host：Rabbit
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| Name | Anti-MAEA Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Predicted Reactivity | Bovine;Chicken;Orangutan |
| Dilution Ratio | WB 1:2000-5000. IHC 1:50-200. |
| Target | MAEA |
| Background | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972).MAEA is required for normal cell proliferation (PubMed:29911972).The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity).Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581).Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity).May contribute to nuclear architecture and cells division events (Probable). |
| Swiss Prot | Q7L5Y9 |
| Gene ID | 10296 |
| Subcellular Location | Cytoplasm Nucleus |
| Immunogen | Recombinant protein of human MAEA |
| Public Immunogen Range | 1-350aa |
| Calculated MW | 27/36/40/41/45kDa |
| Observed MW | 47kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | Piece |
| Specification | 20ul 50ul 100ul |
| Reactivity | Human Mouse Rat |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with MAEA antibody diluted at 1:2000;Lane: HepG2,COLO205.
Immunohistochemistry of paraffin-embedded Human breast cancer with MAEA antibody diluted at 1:100.
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