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My CartReactivity：Human
Application：WB,IHC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：388677
Host：Rabbit
Qty：
Size：
| Name | Anti-NOTCH2NL Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | WB 1:2000-5000. IHC 1:25-100. |
| Target | NOTCH2NL |
| Background | Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway.Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes,thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production.Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect.Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2.Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation. |
| Swiss Prot | Q7Z3S9 |
| Gene ID | 388677 |
| Subcellular Location | Cytoplasm |
| Immunogen | Recombinant protein of human NOTCH2NL |
| Public Immunogen Range | 1-237aa |
| Calculated MW | 25/26/27kDa |
| Observed MW | 24kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | Piece |
| Specification | 20ul 50ul 100ul |
| Reactivity | Human |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with NOTCH2NL antibody diluted at 1:2000;Lane: A549,HEL,PC-3M-IE8,U251,THP-1.
Immunohistochemistry of paraffin-embedded Human thyroid cancer with NOTCH2NL antibody diluted at 1:50.
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