{{cart_num}}
My CartReactivity：Mouse,Human
Application：IHC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：147040
Host：Rabbit
Qty：
Size：
| Name | Anti-KCTD11 Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Predicted Reactivity | Bovine; |
| Dilution Ratio | IHC 1:50-200. |
| Target | KCTD11 |
| Background | Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals; such as retinoic acid; epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis; growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1; thus maintaining cerebellar granule cells in undifferentiated state; this effect probably occurs via HDAC1 down-regulation; keeping GLI1 acetylated and inactive. When knock-down; Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. |
| Swiss Prot | Q693B1 |
| Gene ID | 147040 |
| Subcellular Location | Cytoplasm Nucleus Cell membrane |
| Immunogen | Recombinant protein of human KCTD11 |
| Public Immunogen Range | 1-233aa |
| Calculated MW | 26/30kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | bottle |
| Specification | 20ul 50ul 100ul |
| Reactivity | Human Mouse |
| Application | IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with KCTD11 antibody diluted at 1:100.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
