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My CartReactivity：Mouse,Human
Application：RBITC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：147040
Host：Rabbit
Qty：
Size：
| Reactivity | Mouse,Human |
| Background | Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals; such as retinoic acid; epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis; growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1; thus maintaining cerebellar granule cells in undifferentiated state; this effect probably occurs via HDAC1 down-regulation; keeping GLI1 acetylated and inactive. When knock-down; Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. |
| Subtype | IgG |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Host | Rabbit |
| Application | IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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