Gene Name |
NR3C1 |
Synonyms |
GCCR;GCR;GCRST;GR;GRL;glucocorticoid receptor |
English Name |
Recombinant human NR3C1 protein |
Full Name |
nuclear receptor subfamily 3,group C,member 1 |
Chinese Name |
核受体亚家族3,C组成员1 |
Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Purity |
≥85% by SDS-PAGE. |
Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year. |
Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
Concentration |
1mg/ml by SDS-PAGE. |
Swiss Prot |
P04150 |
Gene ID |
2908 |
Reactivity |
Human Mouse Rat (Rabbit Pig Sheep Monkey Gorilla) |
Molecular Weight |
33kDa |
Interval Range |
1-300aa |
Background |
Receptor for glucocorticoids (GC) (PubMed:27120390).Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors.Affects inflammatory responses, cellular proliferation and differentiation in target tissues.Involved in chromatin remodeling (PubMed:9590696).Mutations in this gene are associated with generalized glucocorticoid resistance.Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms.Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). |
Application |
Immunology research |
Source |
E.coli |
Purification Method |
NI-NTA affinity purification |
Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
Endotoxin |
Not measured |
Biological Activity |
N0 |
Lable Information |
With a 6×His tag at the N/C-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |