Gene Name |
ABAT |
Synonyms |
ABAT,GABA aminotransferase,GABA AT,GABA T,GABA transaminase,GABAT,L AIBAT |
English Name |
Recombinant human ABAT protein |
Full Name |
4-aminobutyrate aminotransferase |
Chinese Name |
4-氨基丁酸酯氨基转移酶 |
Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Purity |
≥85% by SDS-PAGE. |
Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year. |
Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
Concentration |
1mg/ml by SDS-PAGE. |
Swiss Prot |
/ |
Gene ID |
18 |
Reactivity |
/ |
Molecular Weight |
13kDa |
Interval Range |
1-116aa |
Background |
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde.The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate.The protein sequence is over 95% similar to the pig protein.GABA is estimated to be present in nearly one-third of human synapses.ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44.The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. |
Application |
Immunology research |
Source |
E.coli |
Purification Method |
NI-NTA affinity purification |
Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
Endotoxin |
Not measured |
Biological Activity |
N0 |
Lable Information |
With a 6×His tag at the N/C-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |