Gene Name |
TIRAP |
Synonyms |
TIRAP;BACTS1;Mal;MyD88-2;wyatt;TIR domain containing adaptor protein |
English Name |
Recombinant human TIRAP protein |
Full Name |
toll-interleukin 1 receptor (TIR) domain containing adaptor protein |
Chinese Name |
含Toll-白细胞介素1受体(TIR)结构域的接头蛋白 |
Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Purity |
≥85% by SDS-PAGE. |
Storage |
Reconstituted protein solution can be stored at 4-7℃ for 2-7 days, stored at < -20℃ for 1 year. |
Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
Concentration |
1mg/ml by SDS-PAGE. |
Swiss Prot |
P58753 |
Gene ID |
114609 |
Reactivity |
Human Mouse |
Molecular Weight |
28kDa |
Interval Range |
1-257aa |
Background |
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns.Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction.The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system.It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response.Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. |
Application |
Immunology research |
Source |
E.coli |
Purification Method |
NI-NTA affinity purification |
Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 10μg/ml. Dissolve the lyophilized protein in distilled water.) |
Endotoxin |
Not measured |
Biological Activity |
No activity experimental data, to be verified. |
Lable Information |
With a 6×His tag at the N/C-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |