| Gene Name |
TRPM8 |
| Synonyms |
TRPM8;LTRPC6;TRPP8;transient receptor potential cation channel subfamily M member 8 |
| English Name |
Recombinant human TRPM8 protein |
| Full Name |
transient receptor potential cation channel，subfamily M，member 8 |
| Chinese Name |
瞬时受体电位阳离子通道M亚家族成员8 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q7Z2W7 |
| Gene ID |
79054 |
| Reactivity |
Human Mouse Rat |
| Molecular Weight |
23kDa |
| Interval Range |
1-192aa |
| Background |
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius.Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH.Involved in menthol sensation.Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium.Temperature sensing is tightly linked to voltage-dependent gating.Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves.The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials.Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity.Plays a role in prostate cancer cell migration .Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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