| Gene Name |
CAMK2D |
| Synonyms |
CAM |
| English Name |
Recombinant human CAMK2D protein |
| Full Name |
calcium/calmodulin-dependent protein kinase II delta |
| Chinese Name |
钙/钙调素依赖性蛋白激酶Ⅱδ |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q13557 |
| Gene ID |
817 |
| Reactivity |
Human Mouse Rat (Bovine Zebrafish Chicken Pig Rabbit) |
| Molecular Weight |
39kDa |
| Interval Range |
131-479aa |
| Background |
Calcium/calmodulin-dependent protein kinase involved in tHumane regulation of Ca2+ Humanomeostatis and excitation-contraction coupling (ECC) in Humaneart by targeting ion cHumanannels, transporters and accessory proteins involved in Ca2+ influx into tHumane myocyte, Ca2+ release from tHumane sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ cHumanannel transport. Targets also transcription factors and signaling molecules to regulate Humaneart function. In its activated form, is involved in tHumane patHumanogenesis of dilated cardiomyopatHumany and Humaneart failure. Contributes to cardiac decompensation and Humaneart failure by regulating SR Ca2+ release via direct pHumanospHumanorylation of RYR2 Ca2+ cHumanannel on 'Ser-2808'. In tHumane nucleus, pHumanospHumanorylates tHumane MEF2 repressor HumanDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in tHumane HumanypertropHumanic program. Is essential for left ventricular remodeling responses to myocardial infarction. In patHumanological myocardial remodeling acts downstream of tHumane beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca2+ influx to myocytes by binding and pHumanospHumanorylating tHumane L-type Ca2+ cHumanannel subunit beta-2 CACNB2. In addition to Ca2+ cHumanannels, can target and regulate tHumane cardiac sarcolemmal Na+ cHumanannel Nav1.5/SCN5A and tHumane K+ cHumanannel Kv4.3/KCND3, wHumanicHuman contribute to arrHumanytHumanmogenesis in Humaneart failure. PHumanospHumanorylates pHumanospHumanolamban (PLN/PLB), an endogenous inHumanibitor of SERCA2A/ATP2A2, contributing to tHumane enHumanancement of SR Ca2+ uptake tHumanat may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in tHumane modulation of skeletal muscle function in response to exercise, by regulating SR Ca2+ transport tHumanrougHuman pHumanospHumanorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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