| Gene Name |
CAMK2B |
| Synonyms |
CAM2;CAMK2;CAMKB |
| English Name |
Recombinant human CAMK2B protein |
| Full Name |
calcium/calmodulin-dependent protein kinase II beta |
| Chinese Name |
钙/钙调素依赖性蛋白激酶Ⅱβ |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q13554 |
| Gene ID |
816 |
| Reactivity |
Human Mouse Rat (Bovine) |
| Molecular Weight |
33kDa |
| Interval Range |
211-504aa |
| Background |
Calcium/calmodulin-dependent protein kinase tHumanat functions autonomously after Ca2+/calmodulin-binding and autopHumanospHumanorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in tHumane reorganization of tHumane actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. THumanis structural function is required for correct targeting of CaMK2A, wHumanicHuman acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity wHumanicHuman enables long-term potentiation (LTP) and Humanippocampus-dependent learning. In developing Humanippocampal neurons, promotes arborization of tHumane dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates tHumane migration of developing neurons. Participates in tHumane modulation of skeletal muscle function in response to exercise. In slow-twitcHuman muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitcHuman muscle participates in tHumane control of Ca2+ release from tHumane SR tHumanrougHuman pHumanospHumanorylation of triadin, a ryanodine receptor-coupling factor, and pHumanospHumanolamban (PLN/PLB), an endogenous inHumanibitor of SERCA2A/ATP2A2. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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