Gene Name |
RAB3A |
Synonyms |
/ |
English Name |
Recombinant human RAB3A protein |
Full Name |
RAB3A,member RAS oncogene family |
Chinese Name |
RAB3A,RAS致癌基因家族成员 |
Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Purity |
≥85% by SDS-PAGE. |
Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year. |
Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
Concentration |
1mg/ml by SDS-PAGE. |
Swiss Prot |
P20336 |
Gene ID |
5864 |
Reactivity |
Human Mouse Rat (Pig Bovine) |
Molecular Weight |
25kDa |
Interval Range |
1-220aa |
Background |
Small GTP-binding protein that plays a central role in regulated exocytosis and secretion.Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane.Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane.Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed.Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells.Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9.Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1.Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. |
Application |
Immunology research |
Source |
E.coli |
Purification Method |
NI-NTA affinity purification |
Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
Endotoxin |
Not measured |
Biological Activity |
N0 |
Lable Information |
With a 6×His tag at the N/C-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |