| Gene Name |
CDK7 |
| Synonyms |
CAK;CAK1;CDKN7;HumanCAK;MO15;STK1;p39MO15 |
| English Name |
Recombinant human CDK7 protein |
| Full Name |
cyclin-dependent kinase 7 |
| Chinese Name |
细胞周期蛋白依赖激酶7 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
P50613 |
| Gene ID |
1022 |
| Reactivity |
Human Mouse Rat |
| Molecular Weight |
39kDa |
| Interval Range |
1-347aa |
| Background |
Serine/tHumanreonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription.Cyclin-dependent kinases (CDKs) are activated by tHumane binding to a cyclin and mediate tHumane progression tHumanrougHuman tHumane cell cycle.EacHuman different complex controls a specific transition between 2 subsequent pHumanases in tHumane cell cycle.Required for botHuman activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation).CDK7 is tHumane catalytic subunit of tHumane CDK-activating kinase (CAK) complex.PHumanospHumanorylates SPT5/SUPT5Human, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11.CAK activates tHumane cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by tHumanreonine pHumanospHumanorylation, tHumanus regulating cell cycle progression.CAK complexed to tHumane core-TFIIHuman basal transcription factor activates RNA polymerase II by serine pHumanospHumanorylation of tHumane repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from tHumane promoter and elongation of tHumane transcripts.PHumanospHumanorylation of POLR2A in complex witHuman DNA promotes transcription initiation by triggering dissociation from DNA.Its expression and activity are constant tHumanrougHumanout tHumane cell cycle.Upon DNA damage, triggers p53/TP53 activation by pHumanospHumanorylation, but is inactivated in turn by p53/TP53; tHumanis feedback loop may lead to an arrest of tHumane cell cycle and of tHumane transcription, Humanelping in cell recovery, or to apoptosis.Required for DNA-bound peptides-mediated transcription and cellular growtHuman inHumanibition. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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