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My Cart> Antibodies > Primary Antibodies > Anti-E2F1 Polyclonal AntibodySAlexa Fluor 350Reactivity：Mouse,Rat,Human
Application：SAlexa Fluor 350
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：1869
Purity：E2F1
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| Reactivity | Mouse,Rat,Human |
| Background | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain， a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP)， a transactivation domain enriched in acidic amino acids， and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members， E2F2 and E2F3， have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. |
| Subtype | IgG |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Application | WB |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
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