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My CartReactivity：Human,Mouse,Rat
Application：Cy3
Clone Type：Monoclonal Antibody
Storage：Store at -20℃.Avoid freeze/thaw cycles.
Gene ID：8678
Purity：Beclin 1
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Size：
| Reactivity | Human,Mouse,Rat |
| Background | Beclin 1 also known as ATG6 or VPS30 interacts with various cofactors (e.g.Ambra1 Barkor (Atg14) Rubicon or UVRAG) to regulate the lipid kinase Vps34 and promote the formation of the BECLIN1-Vps34-Vps15 complex hence inducing autophagy.Its function (via the BH3 domain) is inhibited by Bcl-2 or Bcl-XL.Beclin 1 (BECN1) is a crucial molecule in the control of the autophagic activity and its activity is regulated by multiple mechanisms including the post-translational modification protein-protein interaction and subcellular localization.It plays a role in crosstalk between apoptosis and autophagy.It has been reported that Beclin 1 can be cleaved into fragments of 50 37 and 35 kDa during apoptosis.It is involved in many disorders including neurodegeneration and cancer (tumorigenesis).Beclin 1 is a mammalian tumor suppressor and its gene is monoallelically deleted in 75% of ovarian 50% of breast and 40% of prostate cancers.Decreased expression of Beclin 1 has also been observed in human brain and lung tumors.The le |
| Subtype | IgG1 |
| Storage | Store at -20℃.Avoid freeze/thaw cycles. |
| Application | WB IHC IF ELISA |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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