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My CartReactivity：Human,Mouse
Application：WB,IHC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：55218
Purity：EXD2
Qty：
Size：
| Name | Anti-EXD2 Polyclonal Antibody |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | WB 1:1000-3000.IHC 1:50-200. |
| Target | Rabbit |
| Background | Exonuclease that has both 3’-5’ exoribonuclease and exodeoxyribonuclease activities， depending on the divalent metal cation used as cofactor (PubMed:29335528， PubMed:31127291).In presence of Mg2+， only shows 3’-5’ exoribonuclease activity， while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn2+ (PubMed:29335528， PubMed:31127291).Acts as an exoribonuclease in mitochondrion， possibly by regulating ATP production and mitochondrial translation (PubMed:29335528).Also involved in the response to DNA damage (PubMed:26807646， PubMed:31255466).Acts as 3’-5’ exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073， PubMed:26807646).Plays a key role in controlling the initial steps of chromosomal break repair， it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3’-5’ exonuclease activity， which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646).Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression， thereby suppressing their degradation (PubMed:31255466). |
| Swiss Prot | Q9NVH0 |
| Gene ID | 55218 |
| Subcellular Location | Cytoplasm Nucleus |
| Immunogen | Recombinant protein of human EXD2 |
| Public Immunogen Range | 101-400aa |
| Calculated MW | 56/70kDa |
| Observed MW | Bovine |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol， 0.03% Proclin300， 0.5% BSA， pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Purity | EXD2 |
| Conjugation Concentration | bottle |
| Conjugation | 66kDa |
| Specification | 50ul 100ul |
| Reactivity | Human Mouse |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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