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My CartReactivity：Human,Mouse
Application：HRP
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：55218
Purity：EXD2
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| Reactivity | Human,Mouse |
| Background | Exonuclease that has both 3’-5’ exoribonuclease and exodeoxyribonuclease activities， depending on the divalent metal cation used as cofactor (PubMed:29335528， PubMed:31127291).In presence of Mg2+， only shows 3’-5’ exoribonuclease activity， while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn2+ (PubMed:29335528， PubMed:31127291).Acts as an exoribonuclease in mitochondrion， possibly by regulating ATP production and mitochondrial translation (PubMed:29335528).Also involved in the response to DNA damage (PubMed:26807646， PubMed:31255466).Acts as 3’-5’ exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073， PubMed:26807646).Plays a key role in controlling the initial steps of chromosomal break repair， it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3’-5’ exonuclease activity， which efficiently |
| Subtype | IgG |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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