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My Cart> Antibodies > Primary Antibodies > Anti-PTPRS Polyclonal AntibodySAlexa Fluor 647Reactivity：Rat,Mouse,Human
Application：SAlexa Fluor 647
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：5802
Purity：PTPRS
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Size：
| Reactivity | Rat,Mouse,Human |
| Background | Cell surface receptor that binds to glycosaminoglycans， including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754).Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans， also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development， especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829).Mediates dephosphorylation of NTRK1， NTRK2 and NTRK3 (By similarity).Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity).Down-regulates TLR9-mediated activation of NF-kappa-B， as well as production of TNF， interferon alpha and interferon beta |
| Subtype | IgG |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Application | IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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